Unexpected Pregnancies Linked to Weight Loss Drugs Ozempic and Wegovy

An increasing number of women are reporting unplanned pregnancies while taking popular weight loss medications like Ozempic and Wegovy, even among those who have struggled with fertility issues. These drugs, originally developed to control blood glucose levels in people with type 2 diabetes, have gained popularity for their weight loss effects. However, the growing number of unexpected pregnancies has raised concerns about the safety of these medications during pregnancy.

Doctors are still trying to determine the exact effect, if any, that these glucagon-like peptide-1 receptor agonists (GLP-1 RAs) may have on fertility. Some experts believe that the weight loss induced by these drugs can improve fertility issues caused by obesity, as regular menstrual cycles can resume. Another possibility is that the active ingredient, semaglutide, may interact with contraceptive pills, diminishing their ability to prevent pregnancy. However, more research is needed to confirm any connection.

The unexpected pregnancies, dubbed "Ozempic babies" or "oops babies," have led some doctors to prescribe these drugs off-label to treat polycystic ovary syndrome (PCOS), a leading cause of infertility. While initial safety data looks promising, experts are divided on how soon patients should stop taking the drugs before trying to conceive. Animal studies have suggested potential fetal risks, and guidelines recommend effective birth control for female users and at least a two-month window after stopping before attempting conception.

Why this matters: The growing number of unexpected pregnancies linked to weight loss drugs like Ozempic and Wegovy highlights the need for more research on the potential effects of these medications on fertility and pregnancy outcomes. As the use of these drugs expands worldwide, it is crucial to ensure the safety of both the mother and the developing fetus.

Researchers are conducting studies to better understand the impact of these medications on fertility and pregnancy, but companies have not systematically studied their use in PCOS. The lack of data makes it a "bit scary" for doctors to move forward without more information, according to experts. Women considering or using semaglutide before, during, or after pregnancy should consult with a healthcare provider to manage their condition and ensure the best start for their baby.

Key Takeaways

• Unexpected pregnancies reported in women taking weight loss drugs like Ozempic and Wegovy.
• Experts unsure if these drugs affect fertility, but weight loss may improve fertility issues.
• Doctors prescribing these drugs off-label to treat PCOS, but safety data is limited.
• Animal studies suggest potential fetal risks, guidelines recommend effective birth control.
• More research needed on the impact of these medications on fertility and pregnancy outcomes.