Rare Case of Overlapping CIDP and NMOSD Successfully Treated

Researchers at Rumah Sakit Umum Daerah Dr. Moewardi Surakarta in Indonesia reported a rare case of a 49-year-old woman diagnosed with overlapping chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and neuromyelitis optica spectrum disorder (NMOSD), successfully treated with a combination of corticosteroids and immunosuppressants. The patient's symptoms improved significantly after treatment, highlighting the importance of accurate diagnosis and timely intervention in managing complex neurological conditions." This description focuses on the primary topic of the rare case study, the main entity being the patient, and the context of the hospital in Indonesia. It also highlights the significant action of successful treatment and its consequences, which is the improvement of the patient's symptoms. The description provides objective and relevant details that will guide the AI in creating an accurate visual representation of the article's content, such as a hospital setting, medical professionals, and possibly a patient receiving treatment.

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Aqsa Younas Rana
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Rare Case of Overlapping CIDP and NMOSD Successfully Treated

Rare Case of Overlapping CIDP and NMOSD Successfully Treated

Researchers at Rumah Sakit Umum Daerah Dr. Moewardi Surakarta in Indonesia have reported a rare case of a 49-year-old woman who presented with an overlap of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and neuromyelitis optica spectrum disorder (NMOSD). The patient was successfully treated with a combination of corticosteroids and immunosuppressants.

Why this matters: This rare case highlights the importance of accurate diagnosis and timely treatment in managing complex neurological conditions, which can have a significant impact on patients' quality of life. The successful treatment of this patient also underscores the need for further research into the diagnosis and management of overlapping CIDP and NMOSD, which can inform treatment strategies for similar cases in the future.

The patient was diagnosed with both CIDP and NMOSD after presenting with severe acute-onset vertigo, nausea, vomiting, hiccups, and blurry vision, as well as progressive weakness in the lower and upper extremities. She was administered pulse therapy with high-dose corticosteroids (1000 mg, q.1.d) for 3 days, followed by a regimen of methotrexate (25 mg each week), azathioprine (50 mg t.i.d.), and prednisone (5 mg t.i.d).

Following the treatment, the patient's symptoms improved significantly, with vertigo, nausea, and vomiting subsiding. She was discharged from the hospital 7 days after admission. The diagnosis of CIDP was supported by findings of albumino-cytological dissociation in the cerebrospinal fluid and reduced compound muscle action potentials in the nerve conduction study.

The diagnosis of NMOSD was supported by the recurrence of blurry vision and positive aquaporin-4, as well as the presence of bilateral pre-chiasmal lesions and somatosensory evoked potential. The lead author of the study was Baarid Luqman Hamidi, MD, a neurologist at Rumah Sakit Umum Daerah Dr. Moewardi Surakarta in Indonesia.

This rare case highlights the successful treatment of a patient presenting with overlapping CIDP and NMOSD using a combination of corticosteroids and immunosuppressants. The findings underscore the importance of prompt diagnosis and appropriate therapeutic intervention in managing such complex neurological conditions.

Key Takeaways

  • Researchers report a rare case of overlapping CIDP and NMOSD in a 49-year-old woman.
  • Combination therapy with corticosteroids and immunosuppressants showed efficacy in treating the condition.
  • Patient presented with severe vertigo, nausea, vomiting, and progressive weakness in extremities.
  • Diagnosis was supported by albumino-cytological dissociation and reduced compound muscle action potentials.
  • Prompt diagnosis and treatment are crucial in managing complex neurological conditions.